Low-frequency vibrational properties of crystalline and glassy indomethacin probed by terahertz time-domain spectroscopy and low-frequency Raman scattering

• Vibrational properties of pharmaceutical indomethacin were investigated.
• The dielectric spectra of glassy and crystalline state were compared with Raman spectra.
• Remarkable differences were observed between the dielectric and Raman spectra.
• Low-frequency Raman scattering spectra clearly showed the boson peak.

In order to clarify the intermolecular vibrations, the low-frequency modes of the glassy and crystalline states of model pharmaceutical indomethacin have been studied using broadband terahertz time-domain spectroscopy and low-frequency Raman scattering. In the crystalline γ-form, the center of symmetry was suggested by the observation of the exclusion principle of the infrared (IR) and Raman selection rules in the frequency range between 0.2 and 6.5 THz. In addition, a boson peak of the glassy state was observed in both IR and Raman spectra and their frequency showed apparent discrepancy. The intermediate correlation length of the glassy structure was estimated to be about 2.5 nm. The existence of hydrogen bonded cyclic dimers in a glassy state was suggested by the observation of the infrared active intermolecular vibrational mode of the hydrogen bonded cyclic dimers as a broad peak at 3.0 THz in the IR spectrum.

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