Spectral, thermal and biological studies of Mn(II) and Cu(II) complexes with two thiosemicarbazide derivatives

Two derivatives of thiosemicarbazide were prepared. Their complexes were prepared using Mn(II) and Cu(II) salts. All the isolated complexes are characterized using the following spectra: IR, UV–Vis, Mass, 1H NMR and X-ray diffraction. Magnetic measurements and thermal analysis are the other additive tools for complete investigation. Mononuclear and binuclear complexes are proposed based on elemental analysis mainly. The IR spectra offer the mode of coordination of each ligand with each metal ion. The electronic spectra and magnetic measurements are proposing the structural geometry of the investigated complexes. The octahedral geometry proposed for Mn(II) complexes but the square–planar for Cu(II) complexes. The 1H NMR spectra were done for all organic compounds used in this study and displaying the most suitable tautomer of them. X-ray diffraction of H2L1 and its complexes show their amorphous nature but H2L2 ligand and its complexes show their nanocrystalline nature. The TG analysis was used to prove the presence of solvent molecules attached with the complexes as covalently or physically. Finally, the biological investigation was carried out for H2L2 ligand and its complexes and displaying the inhibition activity of Cu(II) complex than the Mn(II) one.

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► This work dealing two of new thiosemicarbazide complexes.
► Structural and spectral properties were discussed.
► Antimicrobial activities of complexes recorded shining values.