Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of raceanisodamine hydrochloride and atropine sulfate in biological fluids

Now, the development of quantum dots (QDs)-based fluorescence sensors become very quickly, but as phosphorescence compared to fluorescent has many advantages, like longer shine time and emission wavelength. Therefore, the phosphorescence properties of QDs and their potential for phosphorescence detection have raised great concerns. In this paper, a novel room-temperature phosphorescence (RTP) quenching method was developed by Mn-doped ZnS quantum dots (QDs). The developed method is employed for detection of the raceanisodamine hydrochloride and atropine sulfate in biological fluids. The results showed a high selectivity of the Mn-doped ZnS QDs toward these medicines by phosphorescence quenching. Under the optimized experimental conditions, the detection limits (3 s) for raceanisodamine hydrochloride and atropine sulfate were 0.11 μM, 0.09 μM, respectively. The relative standard deviations for eleven replicate detections of 2.0 μM were 0.92–1.6%. The recovery of spiked solutions in human urine and serum samples ranged from 95% to 104%.

RTP spectra of Mn-doped ZnS QDs (curve a) and after the adding raceanisodamine hydrochloride (curve b) and atropine sulfate (curve c).Figure optionsDownload as PowerPoint slideHighlights
► Synthesis and characterization of the Mn-doped ZnS QDs.
► Effect of pH on the phosphorescence intensity of the Mn-doped ZnS QDs.
► Mechanism of the Mn-doped ZnS QDs for the RTP detection of the medicines.