Hydrolysis of Letrozole catalyzed by macrocyclic Rhodium (I) Schiff-base complexes

• Mononuclear Rhodium (I) complexes with macrocyclic ligands having N4 and N2O2 donor sites were reported.
• Investigated as effective catalysts in hydrolysis of Nitrile group containing pharmaceutical drug Letrozole.
• Catalytic procedure involves mild reaction condition and easy to work-up.
• This approach can be effectively used for the hydrolysis of Nitrile group containing APIs.

Ten mononuclear Rhodium (I) complexes were synthesized by macrocyclic ligands having N4 and N2O2 donor sites. Square planar geometry is assigned based on the analytical and spectral properties for all complexes. Rh(I) complexes were investigated as catalysts in hydrolysis of Nitrile group containing pharmaceutical drug Letrozole. A comparative study showed that all the complexes are efficient in the catalysis. The percent yields of all the catalytic reaction products viz. drug impurities were determined by spectrophotometric procedures and characterized by spectral studies.

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