کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1233054 968802 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, DNA-binding and photocleavage studies of [Ru(phen)2(pbtp)]2+ and [Ru(bpy)2(pbtp)]2+ (phen = 1,10-phenanthroline; bpy = 2,2′-bipyridine; pbtp = 4,5,9,11,14-pentaaza-benzo[b]triphenylene)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Synthesis, DNA-binding and photocleavage studies of [Ru(phen)2(pbtp)]2+ and [Ru(bpy)2(pbtp)]2+ (phen = 1,10-phenanthroline; bpy = 2,2′-bipyridine; pbtp = 4,5,9,11,14-pentaaza-benzo[b]triphenylene)
چکیده انگلیسی

Based on the ligand dppz (dppz = dipyrido-[3,2-a:2′,3′-c]phenazine), a new ligand pbtp (pbtp = 4,5,9,11,14-pentaaza-benzo[b]triphenylene) and its polypyridyl ruthenium(II) complexes [Ru(phen)2(pbtp)]2+ (1) (phen = 1,10-phenanthroline and [Ru(bpy)2(pbtp)]2+ (2) (bpy = 2,2′-bipyridine) have been synthesized and characterized by elemental analysis, ES-MS and 1H NMR spectroscopy. The DNA-binding of these complexes were investigated by spectroscopic methods and viscosity measurements. The experimental results indicate that both complexes 1 and 2 bind to CT-DNA in classical intercalation mode, and can enantioselectively interact with CT-DNA. It is interesting to note that the pbtp ruthenium(II) complexes, in contrast to the analogous dppz complexes, do not show fluorescent behavior when intercalated into DNA. When irradiated at 365 nm, both complexes promote the photocleavage of pBR 322 DNA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 73, Issue 5, 1 September 2009, Pages 858–864
نویسندگان
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