Diorganotin(IV) complexes of biologically potent 4(3H)-quinazolinone derived Schiff bases: Synthesis, spectroscopic characterization, DNA interaction studies and antimicrobial activity

Four Schiff base ligands and their corresponding organotin(IV) complexes have been synthesized and characterized by elemental analyses, IR, 1H NMR, MS and thermal studies. The Schiff bases are obtained by the condensation of 3-amino-2-methyl-4(3H)-quinazolinone with different substituted aldehydes. The elemental analysis data suggest the stoichiometry to be 1:1 ratio formation. Infrared spectral data agreed with the coordination to the central metal ion through imine nitrogen, lactam oxygen and deprotonated phenolic oxygen atoms. All the synthesized compounds have been evaluated for antimicrobial activity against selected species of microorganisms. In addition, DNA binding/cleavage capacity of the compounds was analyzed by absorption spectroscopy, viscosity measurements and gel electrophoresis methods.

Four diorganotin(IV) complexes of 4(3H)-quinazolinone derived ligands were prepared and characterized by using spectroscopic techniques. All the compounds were evaluated for antimicrobial activity. The DNA interaction studies of diorganotin(IV) complexes were also performed.Figure optionsDownload as PowerPoint slideHighlights
• We prepared four novel organotin(IV) complexes of Schiff base ligands.
• Spectral characterization of ligands and their organotin(IV) complexes were done.
• Antimicrobial and DNA interaction studies were performed for the prepared compounds.
• Antimicrobial results revealed that the complexes are more active than their ligands.
• Complexes act as avid DNA binders and good cleaving agents.