Synthesis, characterization and antimicrobial studies on cis-platinum(II) complexes of 5-nitrosouracil derivatives

Two complexes were obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil (AMNU) and 6-methylamino-1-benzyl-5-nitrosouracil (MABNU) with cis-diaquadiamineplatinum(II) nitrate complex, cis-[Pt(NH3)2(H2O)2](NO3)2. The complexes were isolated in good yields as powdery precipitates. They were characterized through their elemental analysis, infrared, UV–vis, and 1H NMR spectroscopies as well as thermal analyses. The obtained results indicated that, pyrimidine bases substitute easily aqua ligands and interact with Pt(II) ions as a monodentate ligand in the neutral and ionic form for the ligands AMNU and MABNU, respectively. The exocyclic oxygen atoms are the most probable binding site. Square planar structures, cis-form, were proposed in both cases. The free ligands, and their Pt(II) complexes were screened for their antimicrobial activities.