Synthesis, spectral studies and solvatochromic analysis of novel imidazole derivatives

Bioactive imidazole derivatives were synthesized and characterized by spectral techniques. The photophysical properties of imidazole derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet–Taft and Catalan parameters. The interaction between bioactive imidazole derivative and bovine serum albumin (BSA) was also investigated.

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► Spectral shift is attributed to a loss of planarity in the excited state.
► Spectral shift analyzed by Kamlet–Taft and Catalan parameters.
► The conformational change of BSA due to the presence of imidazole.
► The OH group of Tyr residue for the interaction of BSA with imidazole.
► Static quenching – The donor-to-acceptor distance is <8 nm.