کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1234760 | 1495260 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, characterization and anti-microbial evaluation of Cu(II), Ni(II), Pt(II) and Pd(II) sulfonylhydrazone complexes; 2D-QSAR analysis of Ni(II) complexes of sulfonylhydrazone derivatives Synthesis, characterization and anti-microbial evaluation of Cu(II), Ni(II), Pt(II) and Pd(II) sulfonylhydrazone complexes; 2D-QSAR analysis of Ni(II) complexes of sulfonylhydrazone derivatives](/preview/png/1234760.png)
Copper(II), nickel(II), platinum(II) and palladium(II) complexes with 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) derived from propanesulfonic acid-1-methylhydrazide (psmh) were synthesized, their structure were identified, and antimicrobial activity of the compounds was screened against three Gram-positive and three Gram-negative bacteria. The results of antimicrobial studies indicate that Pt(II) and Pd(II) complexes showed the most activity against all bacteria. The crystal structure of 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) was also investigated by X-ray analysis. A series of Ni(II) sulfonyl hydrazone complexes (1–33) was synthesized and tested in vitro against Escherichia coli and Staphylococcus aureus. Their antimicrobial activities were used in the QSAR analysis. Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO–LUMO energy gap play key roles in the antimicrobial activity.
Plot of observed versus calculated pMIC values of training sets for: (a) E. coli and (b) S. aureusFigure optionsDownload as PowerPoint slideHighlights
► New original sulfonylhydrazine and sulfonylhydrazone complexes were synthesized.
► New synthesized compounds were screened for their antibacterial activity.
► QSAR analysis was performed on Ni(II) sulfonylhdrazone complexes for E. coli and S. aureus.
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 108, May 2013, Pages 123–132