کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1234879 968838 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and antimicrobial investigation of some moxifloxacin metal complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Synthesis, characterization and antimicrobial investigation of some moxifloxacin metal complexes
چکیده انگلیسی

The new complexes of moxifloxacin (MOX), with Ti(IV), Y(III), Pd(II) and Ce(IV) have been synthesized. These complexes were then characterized by melting point, magnetic studies and spectroscopic techniques involving infrared spectra (IR), UV–Vis, 1H NMR. C, H, N and halogen elemental analysis and thermal behavior of complexes also investigated. The results suggested that the molar ratio for all complexes is M: MOX = 1:2 where moxifloxacin acts as a bidentate via one of the oxygen atoms of the carboxylate group and through the ring carbonyl group and the complexes have the following formula [Ti(MOX)2](SO4)2·7H2O, [Y(MOX)2Cl2]Cl·12H2O, [Pd(MOX)2(H2O)2]Cl2·6H2O and [Ce(MOX)2](SO4)2·2H2O. The activation energies, E*, enthalpies, ΔH*, entropies, ΔS* and Gibbs free energies, ΔG*, of the thermal decomposition reactions have been derived from thermogravimetric (TGA) and differential thermogravimetric (DrTG) curves, using Coats–Redfern (CR) and Horowitz–Metzger (HM) methods. The antimicrobial activity of these complexes has been evaluated against three Gram-positive and three Gram-negative bacteria and compared with the reference drug moxifloxacin. The antibacterial activity of Ti(IV) complex is significant for E. coli K32 and highly significant for S. aureus K1, B. subtilis K22, Br. otitidis K76, P. aeruginosa SW1 and K. oxytoca K42 compared with free moxifloxacin.

The synthesis, the characterization and the antibacterial activity of the neutral mononuclear Ti(IV), Y(III), Pd(II) and Ce(IV) complexes with the quinolone antibacterial agent moxifloxacin are presented.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis and isolation of some new complexes with moxifloxacin as antibacterial agent.
► Characterization of the isolated solid complexes by: elemental analysis, IR data and bonding, UV–Vis spectra, thermal studies, the kinetics data, the 1H NMR spectra.
► Studying the effect of the metal ions and their oxidation state on the solubility of antibacterial agent moxifloxacin and also if it increasing or decreasing the activity of antibiotic moxifloxacin inside the human body.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 84, Issue 1, 15 December 2011, Pages 99–110
نویسندگان
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