Microwave assisted synthesis, spectroscopic, electrochemical and DNA cleavage studies of lanthanide(III) complexes with coumarin based imines

The present work stems from our interest in the synthesis, characterization and biological evaluation of lanthanide(III) complexes of a class of coumarin based imines which have been prepared by the interaction of hydrated lanthanide(III) chloride with the sodium salts of 3-acetylcoumarin thiosemicarbazone (ACTSZH) and 3-acetylcoumarin semicarbazone (ACSZH) in 1:3 molar ratio using thermal as well as microwave method. Characterization of the ligands as well as the metal complexes have been carried out by elemental analysis, melting point determinations, molecular weight determinations, magnetic moment, molar conductance, IR, 1H NMR, 13C NMR, electronic, EPR, X-ray powder diffraction and mass spectral studies. Spectral studies confirm ligands to be monofunctional bidentate and octahedral environment around metal ions. The redox behavior of one of the synthesized metal complex was investigated by cyclic voltammetry. Further, free ligands and their metal complexes have been screened for their antimicrobial as well as DNA cleavage activity. The results of these findings have been presented and discussed.

In present investigation, new series of Ln(III) complexes have been synthesized by microwave method, characterized and evaluated for their in vitro antimicrobial and DNA cleavage activity.Figure optionsDownload as PowerPoint slideHighlights
► Lanthanide(III) complexes through microwave synthesis.
► Resulted with good yield, less reaction time.
► Characterized by IR, NMR, EPR, mass spectra, X-ray powder diffraction studies, cyclic voltammetry.
► Show antifungal, antibacterial and DNA cleavage activity.
► Biologically potent coumarin derivatives.