کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1237069 | 968883 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective determination of ertapenem in the presence of its degradation product
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Stability-indicative determination of ertapenem (ERTM) in the presence of its β-lactam open-ring degradation product, which is also the metabolite, is investigated. The degradation product has been isolated, via acid-degradation, characterized and elucidated. Selective quantification of ERTM, singly in bulk form, pharmaceutical formulations and/or in the presence of its major degradant is demonstrated.The indication of stability has been undertaken under conditions likely to be expected at normal storage conditions. Among the spectrophotometric methods adopted for quantification are first derivative (1D), first derivative of ratio spectra (1DD) and bivariate analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 72, Issue 5, June 2009, Pages 915–921
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 72, Issue 5, June 2009, Pages 915–921
نویسندگان
Nagiba Y. Hassan, Ezzat M. Abdel-Moety, Nariman A. Elragehy, Mamdouh R. Rezk,