Efficient synthesis of chromenopyridine and chromene via MCRs

MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions from different salicylaldehydes, malononitrile and different thiols (mol ratio = 1:2:1) were established. Mechanistic investigation suggests that the MCRs undergo different pathways at different temperatures and catalyzed by different organic bases. The structure of chromenopyridine and chromene are confirmed by crystal X-ray crystallography.

MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions, respectively, from different salicylaldehydes, malononitrile and different thiols (mol ratio = 1:2:1) were established.Figure optionsDownload as PowerPoint slide