Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds.

A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cells were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds.Figure optionsDownload as PowerPoint slide