کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1254379 971373 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solubilization of organic compounds by arginine-derived polymers
ترجمه فارسی عنوان
محلول سازی ترکیبات آلی با پلیمرهای مشتق شده از آرژینین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Poor aqueous solubility of drugs is one of the major challenges in the pharmaceutical science. In this study, a guanidinium-containing polymer based on arginine was designed and synthesized, and was evaluated as a solubility enhancing additive for three model organic compounds (coumarin, pyrene and doxorubicin). At a guanidinium group concentration of 100 mmol/L, the polymer could significantly increase the solubility of pyrene and doxorubicin by 6- and 11-fold respectively, much more effective than arginine (2- and 3-fold, respectively). In contrast, its effect on the solubility of coumarin was less effective than arginine. The solubilizing effect may be explained by the enhanced interaction between the guanidinium group in the polymer and the aromatic compounds.

With multiple guanidinium side groups, arginine-derived polymers are very effective to solubilize large aromatic compounds in the aqueous solutions.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 26, Issue 6, June 2015, Pages 636–640
نویسندگان
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