Goniodilactone and gonioheptenolactone, two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis

Two novel styryllactones, goniodilactone (1) and gonioheptenolactone (2), were isolated from the leaves of Goniothalamus cheliensis Hu. Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells, including DU-145, PC-3, MCF-7, A-549, KB and KBvin, with GI50s in the range of 1.29–4.56 μg/mL.