کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1254471 | 971376 | 2016 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A facile synthesis of 6-amino-2H, 4H-pyrano[2,3-с]pyrazole-5-carbonitriles in deep eutectic solvent A facile synthesis of 6-amino-2H, 4H-pyrano[2,3-с]pyrazole-5-carbonitriles in deep eutectic solvent](/preview/png/1254471.png)
A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-с]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes (1a-o) malanonitrile (2), ethyl acetoacetate (3), and hydrazine hydrate (4) in freshly prepared deep eutectic solvent, DES (choline chloride:urea). This protocol has afforded corresponding pyrano[2,3-с]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents.
A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-с]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes (1a-o) malanonitrile (2), ethyl acetoacetate (3), and hydrazine hydrate (4) in freshly prepared deep eutectic solvent, DES (choline chloride:urea). This protocol has afforded corresponding pyrano[2,3-с]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 27, Issue 3, March 2016, Pages 370–374