Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors

A short and efficient synthesis of (Z)-2-substituted-5-(4-((2-substitued-5-oxoimidazolidin-4-ylidene)methyl)benzamido)benzoic acid derivatives (8a–g) as potential type of FabH inhibitors is described. Their structures were confirmed by MS, NOE and 1H NMR.