A catalyst- and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type reaction

A catalyst- and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Mannich type reaction between 7-azaindole, aromatic aldehydes and heterocyclic amines in acceptable to excellent yields. Structures of the compounds were confirmed satisfactorily by 1H NMR, IR, mass, TOCSY, HSQC and HMBC spectral analyses.

A catalyst- and solvent-free protocol for the synthesis of 7-azagramine analogues via a three-component Mannich type reaction is described.Figure optionsDownload as PowerPoint slide