کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1254595 | 971381 | 2016 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: PS-TBD triggered general protocol for the synthesis of 4H-chromene, pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities PS-TBD triggered general protocol for the synthesis of 4H-chromene, pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities](/preview/png/1254595.png)
A general protocol has been developed for the facile construction of titled derivatives via three component reaction between 3-substituted phenyl-1H-pyrazole-4-carbaldehyde, malononitrile and various Michael donors in presence of 5 mol% polystyrene supported 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (PS-TBD). PS-TBD was reused for at least five runs with nearly constant catalytic activity. All compounds were screened for antimicrobial and antioxidant activities.
A new series of 4H-chromene, pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole have been synthesized via three-component reaction (3CR) using recyclable base-catalyst, PS-TBD. All the synthesized compounds have been investigated for their in vitro antimicrobial and antioxidant potency.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 27, Issue 1, January 2016, Pages 168–172