Copper-catalyzed N-arylation of 2-arylindoles with aryl halides

10 mol% CuI combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields. The aryl halides bearing electron-rich or electron-deficient functional groups can be well tolerated under this mild reaction conditions.

Air-stable CuI combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields (up to 98%). The aryl halides bearing electron-rich or electron-deficient functional groups can be well tolerated under this mild reaction conditions.Figure optionsDownload as PowerPoint slide