Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group

A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR, 1H NMR, and HRMS (ESI). Preliminary bioassay showed that some compounds, 5b and 5g, exhibited good activity against soybean aphids (Aphis glycines) at 100 mg L−1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.

In order to find novel neonicotinoids insecticide with good selectivity and activity, a new series of clothianidin analogues with hydrazide group were designed and synthesized. Bioassay result indicated that some compounds showed good insecticidal activity against soybean aphids at 100 mg L−1. Molecular docking study was carried out to explain their different activity from clothianidin.Figure optionsDownload as PowerPoint slide