Rh(I)-catalyzed borylation of primary alkyl chlorides

Rhodium-catalyzed cross-coupling reactions of unactivated primary alkyl chlorides with diboron reagents have been developed as practical methods for the synthesis of alkylboronic esters. These reactions expand the concept and utility of Rh(I)-catalyzed cross-coupling of aliphatic electrophiles.

Rhodium-catalyzed cross-coupling reactions of unactivated primary alkyl chlorides with diboron reagents have been developed as practical methods for the synthesis of alkylboronic esters. These reactions expands the concept and utility of Rh(I)-catalyzed cross-coupling of aliphatic electrophiles.Figure optionsDownload as PowerPoint slide