A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2

A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E (1), was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey's amino acid analysis. Cristatumin E (1) showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.

A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E (1), was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was elucidated by spectroscopic analyses and Marfey's amino acid analysis method. Cristatumin E (1) showed cytotoxicity against K562 tumor cell line with an IC50 value of 8.3 μmol/L.Figure optionsDownload as PowerPoint slide