کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1255552 971430 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design synthesis and biological evaluation of 3-substituted triazole derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Design synthesis and biological evaluation of 3-substituted triazole derivatives
چکیده انگلیسی

Based on the active site of lanosterol 14α-demethylase of azole antifungal agents, sixteen 1-(1H-1,2,4-triazole-1-yl)- 2-(2,4-difluorophenyl)-3-(N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed, synthesized and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 22, Issue 5, May 2011, Pages 519–522
نویسندگان
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