Design, synthesis and biological activity of novel substituted pyrazole amide derivatives targeting EcR/USP receptor

In the basis of core structures of two active compounds 6e and 6i, a series of novel substituted pyrazole amides was obtained and further screened for their insecticidal activities. One target compound 34 displayed excellent activities against lepidopteran pests, and its binding conformation to EcR was studied using molecular docking and molecular dynamics methods, which showed 34 might be the potential inhibitor to EcR and its binding model was similar to that of tebufenozide.