کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1257064 | 971544 | 2013 | 4 صفحه PDF | دانلود رایگان |

A disulfide-modified nucleoside was designed and synthesized. After loading the modified nucleoside on controlled pore glass (CPG), solid phase synthesis strategy was used to prepare peptide–oligonucleotide conjugates (N-3′) containing disulfide bond unit. The 3′-sense strand peptide–siRNA conjugate (VII) maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat. And the sense strand off-target effect of VII decreased remarkably.
Peptide–oligonucleotide conjugates (N-3′) containing disulfide bond unit has been synthesized by solid phase synthesis strategy. The 3′-sense strand peptide conjugated siRNA(VII) maintained good gene silencing activity, and the sense strand off-target effect decreased remarkably.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 24, Issue 10, October 2013, Pages 873–876