کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257064 971544 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid phase synthesis of peptide–siRNA conjugates containing disulfide bond unit
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Solid phase synthesis of peptide–siRNA conjugates containing disulfide bond unit
چکیده انگلیسی

A disulfide-modified nucleoside was designed and synthesized. After loading the modified nucleoside on controlled pore glass (CPG), solid phase synthesis strategy was used to prepare peptide–oligonucleotide conjugates (N-3′) containing disulfide bond unit. The 3′-sense strand peptide–siRNA conjugate (VII) maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat. And the sense strand off-target effect of VII decreased remarkably.

Peptide–oligonucleotide conjugates (N-3′) containing disulfide bond unit has been synthesized by solid phase synthesis strategy. The 3′-sense strand peptide conjugated siRNA(VII) maintained good gene silencing activity, and the sense strand off-target effect decreased remarkably.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 24, Issue 10, October 2013, Pages 873–876
نویسندگان
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