کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257202 971551 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica
چکیده انگلیسی

A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B (1a and 1b), was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD (ECD) calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.

A pair of indole alkaloid enantiomers having a novel bisindolylacetamide skeleton, insatindibisindolamides A and B (1a and 1b), was isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, especially 2D NMR, X-ray crystallography, and electronic CD (ECD) calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 26, Issue 8, August 2015, Pages 931–936
نویسندگان
, , , , , , , , , , , ,