Cp2ZrCl2-catalyzed synthesis of 2-aminovinyl benzimidazoles under microwave conditions

A microwave-assisted general method for the synthesis of 2-aminovinyl benzimidazoles has been developed. Treatment of the 1,2-phenylenediamines and N-arylated/N,N-dialkylated 3-aminoacroleins with bis(cyclopentadienyl)zirconium(IV) dichloride (Cp2ZrCl2) as the catalyst under microwave irradiation for 3–5 min followed by in situ MnO2 oxidation afforded thirteen 2-aminovinyl benzimidazoles in good yields.

A microwave-assisted general method for the synthesis of a diversity of 2-aminovinyl benzimidazoles with Cp2ZrCl2 as the catalyst has been developed.Figure optionsDownload as PowerPoint slide