کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1257556 971569 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of oleanolic disaccharide derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis of oleanolic disaccharide derivatives
چکیده انگلیسی
Oleanolic acid 1 exists widely in food, medicinal herbs and other plants and possesses many attractive biological activities. Recently, some oleanolic derivatives were reported to have interesting anti-tumor activities. Herein, using association principle of drug design, OA disaccharide 17 was designed and synthesized by coupling a-L-rhamnopyranosyl-(1→2)-a-L-arabinopyranosyl disaccharide moiety, which has proved to be a unique sugar sequence with strongly antitumor activity, and modified OA with a nitrile at C-17.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 23, Issue 4, April 2012, Pages 403-406
نویسندگان
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