کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1257831 | 971584 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of novel cytotoxic podophyllotoxin derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of novel cytotoxic podophyllotoxin derivatives Design and synthesis of novel cytotoxic podophyllotoxin derivatives](/preview/png/1257831.png)
چکیده انگلیسی
In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4′-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10−7 mol/L level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 21, Issue 10, October 2010, Pages 1153–1156
Journal: Chinese Chemical Letters - Volume 21, Issue 10, October 2010, Pages 1153–1156
نویسندگان
Wen Li Xi, Qian Cai, Yan Bo Tang, Hua Sun, Zhi Yan Xiao,