DNA cleavage mediated by water-soluble manganese corrole

The DNA nuclease-like activity of a water soluble manganese corrole 5, 10, 15-tris(N-methyl-4-pyridyl)- corrolatomanganese(III) (MnIIITMPyC) has been investigated. MnIIITMPyC may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra, viscosity measurements and CD spectra. MnIIITMPyC exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide.