کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1258453 971619 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines
چکیده انگلیسی

Eight novel 1,4-disubstituted phthalazines (7–14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 19, Issue 1, January 2008, Pages 29–32
نویسندگان
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