Microwave assisted one-pot synthesis of novel molecular clefts with only one chiral arm based on deoxycholic acid

A rapid, safe, and efficient method for the synthesis of novel molecular clefts based on deoxycholic acid was reported. Seven new molecular clefts have been synthesized in good yields (89-98%). This method proved to be extremely simple and highly efficient. The structures of these receptors were confirmed by 1H NMR, IR, MS spectra and elemental analysis.