کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1265161 972197 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ultrasound and microwave assisted synthesis of dihydroxyacetophenone derivatives with or without 1,2-diazine skeleton
ترجمه فارسی عنوان
سنتز سونوگرافی و مایکروویو مشتقات دی هیدروکسی سکتوفنون با یا بدون اسکلت 1،2-دیازین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

A thorough study concerning O-alkylation and α-bromination of dihydroxyacetophenone (DA) and N-alkylation of 1,2-diazine, under ultrasound (US) and microwave (MW) irradiation as well as under conventional thermal heating (TH) is presented. Under US and MW irradiation the yields are higher, the amount of used solvent decreases substantially, the reaction time decreases considerable (from hours or days to minutes) and the consumed energy decreases, consequently the O-alkylation, α-bromination and N-alkylation methods could be considered environmentally friendly. A selective and efficient way to either bis-O-alkylation or mono-O-alkylation of DA has been found, the relative position of the two hydroxyl groups on the phenyl moiety being compulsory. A selective and efficient way for α-bromination in heterogeneous catalysis of DA derivatives under US irradiation is presented. The N-alkylation reaction of DA under US and MW irradiation proved to be the most convenient setup procedure for these types of reactions. Overall, the use of US proved to be more efficient than MW or TH.

A thorough study concerning O-alkylation and α-bromination of dihydroxyacetophenone and N-alkylation of 1,2-diazine, under ultrasound and microwave irradiation as well as under conventional thermal heating is presented.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics Sonochemistry - Volume 21, Issue 2, March 2014, Pages 802–811
نویسندگان
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