کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1266402 | 972275 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficient and highly regioselective synthesis of ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates under ultrasound irradiation
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Efficient and highly regioselective synthesis of ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates under ultrasound irradiation Efficient and highly regioselective synthesis of ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates under ultrasound irradiation](/preview/png/1266402.png)
چکیده انگلیسی
A series of 14 ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates has been synthesized from the cyclocondensation reaction of ethyl 4-methoxy-2-oxoalk[cycloalk]-3-enoates [EtO2CC(O)C(R2)Â =Â C(R1)OR, where RÂ =Â H, Me; R1Â =Â Pr, Ph, 4-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-NO2C6H4, fur-2-yl; R2Â =Â H; R1, R2Â =Â -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-, 3,4-dihydronaphth-2-yl] with 2,4-dichlorophenyl hydrazine hydrochloride under ultrasound irradiation with high regioselectivity and in 71-92% yields. The main goal of this methodology was the significant reduction of reaction times. The compounds were obtained after irradiation for 10-12Â min. In addition, the structure of the ethyl 1H-pyrazole-3-carboxylates was supported by crystallographic data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics Sonochemistry - Volume 18, Issue 1, January 2011, Pages 293-299
Journal: Ultrasonics Sonochemistry - Volume 18, Issue 1, January 2011, Pages 293-299
نویسندگان
Pablo Machado, Glauber R. Lima, Mariane Rotta, Helio G. Bonacorso, Nilo Zanatta, Marcos A.P. Martins,