Electrochemical determination of a hemorheologic drug, pentoxifylline at a multi-walled carbon nanotube paste electrode

The electrochemical oxidation of a hemorheologic drug, pentoxifylline was investigated at a multi-walled carbon nanotubes-paraffin oil paste electrode using cyclic and differential pulse voltammetry. The oxidation process was irreversible over the pH range studied and exhibited an adsorption-controlled behavior. All experimental parameters have been optimized. Under the optimum conditions, the oxidation peak current was linearly proportional to the concentration of pentoxifylline in the range of 3.0 × 10− 5 to 2.0 × 10− 4 M with a detection limit of 1.69 × 10− 7 M by differential pulse voltammetry with 180 s accumulation. The proposed method was successfully applied to pentoxifylline determination in pharmaceutical and urine samples. Satisfactory recoveries of the analyte from the real samples and a good agreement between the concentration ranges studied and the real ranges encountered in the urine samples, when treated with the drug make the developed method applicable in clinical analysis. This method can also be employed in quality control and routine determination of drugs in pharmaceutical formulations.

The electrochemical oxidation of a hemorheologic drug, pentoxifylline was investigated at a multi-walled carbon nanotubes-paraffin oil paste electrode using cyclic and differential pulse voltammetry. Under optimized conditions, the peak current was proportional to pentoxifylline concentration in the range of 3.0 × 10− 5 to 2.0 × 10− 4 M with a detection limit of 1.69 × 10− 7 M by differential pulse voltammetry with 180 s accumulation. The proposed sensitive and simple electrochemical method was successfully applied to pentoxifylline determination in pharmaceutical samples and for the detection of pentoxifylline in urine as a real sample.Figure optionsDownload as PowerPoint slideHighlights
► MWCNTPE has been used for the electrochemical oxidation of a hemorheologic drug, pentoxifylline.
► The electrochemical oxidation was an irreversible and adsorption controlled process.
► For voltammetric determination of pentoxifylline, the detection limit was 1.69 × 10− 7 M.
► The method was used for the analysis of pentoxifylline drug in pharmaceutical and urine samples.
► Proposed method is more sensitive in comparison to reported analytical methods.