کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1267475 | 972353 | 2006 | 9 صفحه PDF | دانلود رایگان |

Facile and practical electrochemical DNA bioassay, X-ray diffraction analysis, synthesis and 1H and 13C NMR data of the 5,5′-disubstituted-3,3′-methanediyl-bis-indoles are reported. On the basis of electrochemical measurements we have hypothesized that the analyzed bis-indoles have an effect on human tumor cells due to DNA binding at adenine-thymidine deoxynucleotides rich region in a concentration/substituent dependent manner. Interesting N–H⋯π and hydrogen-bonding intermolecular interactions were observed which may differentiate their biological features. The 5,5′-dimethoxy-3,3′-methanediyl-bis-indole (2) was found to reduce considerably the growth of cancer cell lines HOP-92 (lung), A498 (renal) and MDA-MB-231/1TCC (breast). The results indicate that title compounds could be interesting as potential antitumoral chemotherapeutics.
Journal: Bioelectrochemistry - Volume 69, Issue 1, September 2006, Pages 1–9