کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1302842 | 974715 | 2006 | 4 صفحه PDF | دانلود رایگان |
A new family of chiral non-racemic bis-oxazolines containing an arylidene bridging unit (and appropriately termed Arylid-Box) have been prepared from malonate esters in satisfactory yields. These ligands have been screened in the Cu(I) catalysed enantioselective cyclopropanation of styrene and α-methylstyrene with ethyl diazoacetate giving enantioselectivities of up to 89% ee. The tBu substituted ligands (2d, 3d and 4d) gave the best ees. Our experiments seemed to indicate that there was no overall dependency of the reaction stereoselectivity or efficiency on reaction conditions, like, solvent, counter ion or temperature.
A series of novel bis-oxazoline ligands with an unusual arylidene back-bone, (appropriately abbreviated to Arylid-Box) have been prepared and used to form Cu(I) complexes in situ for the catalytic asymmetric cyclopropanation of styrene and α-methylstyrene under a variety of conditions. Enantiomeric excesses as high as 89% were obtained.Figure optionsDownload as PowerPoint slide
Journal: Inorganic Chemistry Communications - Volume 9, Issue 8, August 2006, Pages 823–826