کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1302939 | 974723 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Trinuclear Ru(II) polypyridyl complexes as human telomeric quadruplex DNA stabilizers Trinuclear Ru(II) polypyridyl complexes as human telomeric quadruplex DNA stabilizers](/preview/png/1302939.png)
Two new trinuclear ruthenium(II) complexes [(bpy)6Ru3(tpbip)]6+ (1) and [(bpy)6Ru3(tptaip)]6+ (2) (bpy = 2,2′-bipyridine, tpbip = 1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene, tptaip = 2,4,6-tri(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-1,3,5-triazine) have been synthesized and characterized. The interaction of human telomeric DNA with Ru(II) complexes was explored by means of CD spectroscopy, fluorescence titration, ITC and FRET melting. Results indicated that two complexes not only induce a remarkable conformational change of human telomeric DNA, but also have the ability to stabilize the G-quadruplex.
Two trinuclear ruthenium(II) complexes [(bpy)6Ru3(tpbip)]6+ (1) and [(bpy)6Ru3(tptaip)]6+ (2) not only induce a remarkable conformational change of human telomeric DNA, but also have the ability to stabilize the G-quadruplex.Figure optionsDownload as PowerPoint slide
Journal: Inorganic Chemistry Communications - Volume 13, Issue 9, September 2010, Pages 1050–1053