Synthesis of α-trifluoroethoxy-substituted ketones

• An efficient synthesis of α-trifluoroethoxy-substituted ketones has been developed.
• The trifluoroethoxy-substituted pyrazoles synthesis has also been demonstrated.
• A wide range of important functional groups are compatible with this reaction.

A mild and straight-forward synthesis of α-trifluoroethoxy-substituted ketones from the trifluoroethoxylation of α-bromoketones with trifluoroethanol, under Cs2CO3-mediated conditions at room temperature, is described. The utility of this reaction for the synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles is also showed. The reaction tolerates various functional groups and demonstrates efficient scalability and practicality.

A mild and straight-forward synthesis of α-trifluoroethoxy-substituted ketones has been developed. The utility of this reaction for synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles has also been demonstrated.Figure optionsDownload as PowerPoint slide