کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1334889 | 979477 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Platinum(II) complexes of 8-quinolylmethylphosphonates: Synthesis, characterization and antitumour activity Platinum(II) complexes of 8-quinolylmethylphosphonates: Synthesis, characterization and antitumour activity](/preview/png/1334889.png)
A series of novel platinum(II) complexes of diethyl (8-dqmp) and monoethyl (8-Hmqmp) ester of 8-quinolylmethylphosphonic acid has been prepared and studied. It was shown that molecular or ionic complexes could be isolated by reaction of these organophosphorus ligands with [PtX4]2− (X = Cl, Br), depending on the acidity of the reaction solution. In the neutral medium diester formed dihalide adducts, trans-[Pt(8-dqmp)2X2] (1 and 2), with N-bonded ligand through the quinoline nitrogen. Under acidic conditions (pH < 3) both ligands gave the quinolinium salt complexes [LH]2[PtX4] (3 and 4, L = 8-dqmp; 7 and 8, L = 8-Hmqmp), with protonated quinoline ligand as cation and tetrahalidoplatinate complex as anion. By heating in methanol complexes 3 and 4 were converted into the corresponding dimeric hexahalidodiplatinum complexes, [8-Hdqmp]2[Pt2X6] (5 and 6). The chelate complex [Pt(8-mqmp)2] (9), with monoester ligand bonded through the quinoline nitrogen and the deprotonated phosphonic acid oxygen and forming two seven-membered {N, O} chelate rings, was obtained in neutral and basic media by reaction of platinum(II) halides either with sodium or hydrochloride salt of this monoester. The complexes were identified and characterized by elemental and thermogravimetric analyses, conductometric measurements, and by spectroscopic studies. In vitro antitumour activity of complexes was evaluated against the human epidermoid KB and murine leukaemia L1210 cell lines. These results were compared with those obtained for the palladium(II) complexes of the same phosphonate ligands and with those of platinum(II) and palladium(II) complexes of diethyl and monoethyl 2-quinolylmethylphosphonate, in order to correlate the structural and biological properties of quinoline-based aminophosphonate compounds.
A series of novel platinum(II) complexes of diethyl (8-dqmp) and monoethyl (8-Hmqmp) 8-quinolylmethylphosphonates were synthesized and characterized by spectroscopic and thermal studies. Their antiproliferative properties were evaluated against the human and murine cells and structural factors that determine the complex activity were discussed.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 29, Issue 12, 11 August 2010, Pages 2527–2536