کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1335288 | 1500259 | 2014 | 6 صفحه PDF | دانلود رایگان |
Six palladium(II) complexes with (S,S)-R2edda-type esters ((S,S)-R2edda-type: (S,S)-eddch = (S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, 1–3; (S,S)-pddch = (S,S)-propylenediamine-N,N′-di-2-(3-cyclohexyl)propanoate, R = Et, n-Pr, 4, 5; and (S,S)-eddip = (S,S)-ethylenediamne-N,N′-di-2-propanoate, R = i-Am, 6) were synthesized, characterized by IR, NMR spectroscopy, ESI-MS and elemental analysis. DFT calculations indicate that in case of 1–4, the most stable isomers are with (S,S)- and (R,S)-configuration of nitrogen atoms, but for complex 6 (R,R)- and (R,S)-N,N′-configured isomers. Furthermore, complex 5 was obtained as (S,S)-N,N′ configured isomer. Cytotoxicity study was performed against human cervical adenocarcinoma (HeLa), human alveolar basal adenocarcinoma (A549) and non-cancerous human fetal lung fibroblast (MRC-5) cell lines using colorimetric MTT assay. From the investigated palladium(II) complexes 2, 3 and 5 exhibited highest cytotoxic potential against HeLa (IC50: 28.5 ± 3.9, 29.5 ± 1.3 and 34.3 ± 3.2, respectively).
Six new palladium(II) complexes: [PdCl2{(S,S)-R2eddch}], R = Me, Et, n-Pr, 1–3; [PdCl2{(S,S)-R2pddch}], R = Et, n-Pr, 4, 5; [PdCl2{(S,S)-R2eddip}], R = i-Am, 6; were synthesized and characterized. Two diastereoisomers were observed in NMR spectra of 1–4 and 6, but only one for 5. DFT calculations are in agreement with NMR findings. Cytotoxicity of 1–6 was studied on 3 cell lines.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 80, 25 September 2014, Pages 106–111