Synthesis, structure and properties of ruthenium(II) complexes with quinolinedione derivatives as chelate ligands: Crystal structure of [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)]

The reaction of the dimer complex [{Ru(CO)3Cl2}2] with the ligands 4,6-dichloroquinoline-5,8-dione and 6-methoxybenzo[g]quinoline-5,10-dione in ethanol solution led to the neutral mononuclear complexes of general formula [Ru(CO)2Cl2(κ2-quinolinedione-N,O)]. The complexes were characterized by elemental analysis, IR and RMN spectroscopy, and the molecular structure of [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)] was determined by single-crystal X-ray diffraction. The redox chemistry of ligands and complexes was investigated by cyclic voltammetry, and their potential antitumor activity was also evaluated.

The reaction of complex [{Ru(CO)3Cl2}2] with substituted quinolinediones in ethanol yield mononuclear complexes of the type [Ru(CO)Cl2(κ2-quinolinedione-N,O)]. The molecular structure of complex [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)] has been determined by single-crystal X-ray diffraction. The redox chemistry of ligands and complexes was investigated by cyclic voltammetry. The potential antitumor activities of free ligands and the ruthenium complexes are also evaluated.Figure optionsDownload as PowerPoint slide