Synthesis, structural characterization and previous cytotoxicity assay of Zn(II) complex containing 1,10-phenanthroline and 2,2′-bipyridine with valproic acid

A Zn+2 complex of the antiepileptic drug valproic acid (VPA) and the N-donor ligand 2,2′-bipyridine (complex 3) was studied and its toxicity against Artemia salina was evaluated. Two known compounds (1 and 2) were obtained and analyzed for comparison purposes. These compounds were characterized by FTIR, 1H and 13C NMR, HRMS and complexometric titration. The new zinc complex is constituted by two valproate, one N-donor 2,2′-bipy and one hydration water molecule for each metal center (C26H38N2O4Zn). Toxicity against A. salina was also performed, and the new molecule (complex 3, LD50 = 409 μg/mL) showed lower toxicity in comparison with the complex 2 (LD50 = 78 μg/mL) and the free ligand 2,2′-bipy (LD50 = 143 μg/mL). Moreover, the LD50 values were substituent-dependant regarding the N-donor ligand, without VPA influence.

A Zn+2 complex of the antiepileptic drug valproic acid (VPA) and N-donor ligand 2,2′-bipyridine was obtained and its acute toxicity against A. salina was evaluated. For comparison purposes, the related Zn(II) VPA complex alone and with 1,10-phenanthroline complex were prepared.Figure optionsDownload as PowerPoint slide