Structural properties and antibacterial potency of new supramolecular organotin(IV) dithiocarboxylates

A series of new organotin(IV) derivatives; Me3SnL (1), Bu3SnL (2), Ph3SnL (3), Me2SnClL (4), Bu2SnClL (5), Ph2SnClL (6), Et2SnClL (7) and Et2SnL2 (8) where L = N-(2,3-dimethylphenyl)piperazine-1-carbodithioate have been synthesized and characterized by various analytical techniques. Among these techniques, 1H and 13C NMR were carried out to asses solution structures whereas the solid state structures were confirmed by FT-IR and X-ray single crystal analysis (3, 5 and 8). Crystal structure of complex (3) and (5) showed distorted trigonal bipyramidal geometry and square pyramidal geometry, respectively. The inclination of the structure 5 towards square-pyramidal may be due to the presence of the Sn–Cl⋯HN-piperazine hydrogen bonds between the adjacent molecules. A supramolecular structure is shown by compound (8), with central tin atom exists in a distorted octahedral geometry. The antibacterial results indicated the profound activity of the compounds against various strains of bacteria. In addition to this, the triorganotin(IV) derivatives were found more active than diorganotin(IV) compounds.

Eight new organotin(IV) dithiocarboxylates have been synthesized and characterized by different analytical techniques. Secondary non-covalent contacts formation capability of these complexes is not only responsible for structural variation but also have a marked influence on the antibacterial activities.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis of new supramolecular organotin(IV) dithiocarboxylates.
► Non-covalent interactions play a significant role in structural variation.
► Non-covalent contacts may be the cause of their antibacterial action.
► Triorganotin(IV) compounds supersede in activity than diorganotin(IV) ones.