کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1338282 | 979663 | 2007 | 12 صفحه PDF | دانلود رایگان |
A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2′-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines.
Eight Cu(II)carboxylate complexes containing phen, bipy or benzimidazole ligands have been prepared. Crystal structures for three of the complexes are presented. They are poor catalase mimics but they all exhibit excellent SOD activity. Five of the complexes exhibit significant in vitro cytotoxicity against human hepatic, renal and lung cancer cell lines.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 26, Issue 15, 20 September 2007, Pages 4073–4084