کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1338430 | 1500284 | 2013 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of new carborane-based amino acids Synthesis of new carborane-based amino acids](/preview/png/1338430.png)
A series of new boron-containing amino acids 1-HOOCCH(NH2)(CH2)nS-1,2-C2B10H11 (n = 4–6) was prepared by alkylation of 1-mercapto-ortho-carborane with ω-bromoalkylacetamido diethylmalonates followed by acid hydrolysis and decarboxylation. Mild deboronation of the closo-carborane cage with CsF gives cesium salts of the corresponding nido-carborane based amino acids Cs[7-HOOCCH(NH2)(CH2)nS-7,8-C2B9H11] (n = 4–6). The compounds synthesized can be used in radionuclide diagnostics and boron neutron capture therapy of cancer.
A series of new boron-containing amino acids, 1-HOOCCH(NH2)-(CH2)nS-1,2-C2B10H11 and [7-HOOCCH(NH2)(CH2)nS-7,8-C2B9H11]− (n = 4–6), were prepared. The compounds synthesized can be used in radionuclide diagnostics and boron neutron capture therapy of cancer.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 55, 17 May 2013, Pages 117–120