کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1339111 979693 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and DNA binding studies of a polymer-cobalt(III) complex containing the 2,2′-bipyridyl ligand
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Synthesis, characterization and DNA binding studies of a polymer-cobalt(III) complex containing the 2,2′-bipyridyl ligand
چکیده انگلیسی

The polymer-cobalt(III) complex, cis-[Co(bpy)2(BPEI)Cl]Cl2 · 4H2O (bpy = 2,2′-bipyridine, BPEI = branched polyethyleneimine) has been synthesised and characterized. Binding of this polymer-cobalt(III) complex with calf thymus DNA(CT-DNA) was investigated by UV–Visible absorption and fluorescence spectroscopic techniques. Also the interaction of pBR322 DNA with the same polymer-cobalt(III) complex was studied using the gel electrophoresis method. The results indicate that the polymer-cobalt(III) complex interacts with DNA very strongly (Kb = 5.12 × 105 M−1 and Ksv = 0.2023). The nature of the binding seems to be mainly an electrostatic interaction between DNA and the polymer-cobalt(III) complex. Other binding modes, such as hydrogen bonds, may also exist in this system. The high binding constant values indicate the operation of cooperative effects between multiple cobalt(III) complex molecular units and free amine groups, which are present in a single polymer molecule, in binding to DNA.

A polymer-cobalt(III) complex containing the 2,2′-bipyridyl ligand was prepared by the ligand substitution method and characterized. DNA binding studies of this polymer-cobalt(III) complex have been examined by absorption spectroscopy, fluorescence spectroscopy and gel electrophoresis.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polyhedron - Volume 25, Issue 16, 13 November 2006, Pages 3113–3117
نویسندگان
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