کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1339680 | 979712 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Oxidative DNA cleavage by copper ternary complexes of 1,10-phenanthroline and ethylenediamine-sulfonamide derivatives Oxidative DNA cleavage by copper ternary complexes of 1,10-phenanthroline and ethylenediamine-sulfonamide derivatives](/preview/png/1339680.png)
Ternary copper(II) complexes (1–3) of 1,10-phenanthroline and ethylenediamine-R-sulfonamide derivatives (R = benzene, toluene and naphthalene rings) have been synthesized and characterized with the aid of X-ray diffraction and spectroscopic and electrochemical techniques. The crystal structures of the complexes show that the coordination polyhedron around copper(II) is distorted square planar. Both 1,10-phenanthroline and ethylenediamine-R-sulfonamide act as bidentate ligands. The three structures are stabilized by π–π stacking interactions. The interaction of the complexes with calf thymus DNA has been investigated by thermal denaturation studies which indicated that DNA was stabilized in the presence of the compounds. The increase in DNA stability induced by the complexes follows the order: 3 > 2 > 1. All three complexes were found to be very efficient agents of plasmid DNA cleavage in the presence of ascorbate as reducing agent. Mechanistic studies of the DNA cleavage process performed with radical scavengers show that the reactive oxygen species involved in the DNA damage are the hydroxyl radical, singlet oxygen-like species, the superoxide∗ and hydrogen peroxide.
Three ternary copper(II) complexes of 1,10-phenanthroline and ethylenediamine-R-sulfonamide derivatives have been synthesized and structurally characterized. The interaction of the complexes with CT-DNA stabilizes the native DNA conformation. All three complexes were found to be very efficient agents of plasmid DNA cleavage in the presence of ascorbate as reducing agent.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 28, Issue 13, 2 September 2009, Pages 2537–2544